HDAC3

HDAC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4A69
Identifiers
Aliases	HDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
External IDs	MGI: 1343091 HomoloGene: 48250 GeneCards: HDAC3
Gene ontology Molecular function • NAD-dependent histone deacetylase activity (H3-K14 specific) • transcription corepressor activity • histone deacetylase activity • protein deacetylase activity • transcription factor binding • histone deacetylase binding • chromatin binding • NF-kappaB binding • protein binding • enzyme binding • hydrolase activity • cyclin binding Cellular component • cytoplasm • histone deacetylase complex • cytosol • Golgi apparatus • plasma membrane • transcriptional repressor complex • nucleoplasm • spindle microtubule • nucleus Biological process • histone H3 deacetylation • positive regulation of protein phosphorylation • regulation of transcription, DNA-templated • regulation of protein stability • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • cellular response to fluid shear stress • transcription, DNA-templated • positive regulation of transcription factor import into nucleus • spindle assembly • protein deacetylation • negative regulation of JNK cascade • circadian rhythm • negative regulation of myotube differentiation • negative regulation of transcription, DNA-templated • histone deacetylation • positive regulation of TOR signaling • positive regulation of transcription from RNA polymerase II promoter • negative regulation of nucleic acid-templated transcription • covalent chromatin modification • chromatin organization • regulation of lipid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8841	15183
Ensembl	ENSG00000171720	ENSMUSG00000024454
UniProt	O15379	O88895
RefSeq (mRNA)	NM_003883	NM_010411
RefSeq (protein)	NP_003874	n/a
Location (UCSC)	Chr 5: 141.62 – 141.64 Mb	Chr 18: 37.94 – 37.95 Mb
PubMed search

4A69

8841

15183

ENSG00000171720

ENSMUSG00000024454

O15379

O88895

NM_003883

NM_010411

NP_003874

n/a

Histone deacetylase 3 is an enzyme that in humans is encoded by the HDAC3 gene.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

This enzyme is involved in the coordination of commensal-bacteria-dependent intestinal homeostasis when expressed in intestinal epithelial cells.

Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived signals. Studies in mice with a specific deletion of HDAC3 in intestinal epithelial cells (IECs) show a deregulated IEC’s gene expression. In these deletion-mutant mice, loss of Paneth cells, impaired IEC function and alterations in intestinal composition of commensal bacteria were observed. These negative effects were not observed in germ-free mice, indicating that the effects of the deletion are only seen in the presence of intestinal microbial colonization. But the negative effects of HDAC3 deletion are not due to the presence of an altered microbiota because normal germ-free mice colonized with the altered microbiota did not show the negative effects seen in deletion mutants.

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Wikipedia