HCELL

CD44
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Identifiers
Aliases	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
External IDs	OMIM: 107269 MGI: 88338 HomoloGene: 508 GeneCards: CD44
Gene ontology Molecular function • collagen binding • protein binding • hyaluronic acid binding • cytokine receptor activity Cellular component • integral component of membrane • Golgi apparatus • macrophage migration inhibitory factor receptor complex • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • cell surface • extracellular exosome • cytosol • secretory granule membrane • apical plasma membrane • lamellipodium membrane • cell projection Biological process • single organismal cell-cell adhesion • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • monocyte aggregation • positive regulation of heterotypic cell-cell adhesion • hyaluronan catabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • interferon-gamma-mediated signaling pathway • extracellular matrix disassembly • extracellular matrix organization • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • cartilage development • cell adhesion • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell-matrix adhesion • positive regulation of monocyte aggregation • leukocyte migration • neutrophil degranulation • wound healing, spreading of cells • regulation of lamellipodium morphogenesis • positive regulation of kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	960	12505
Ensembl	ENSG00000026508	ENSMUSG00000005087
UniProt	P16070	P15379
RefSeq (mRNA)	NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557	NM_001039150 NM_001039151 NM_001177785 NM_001177786 NM_001177787 NM_009851
RefSeq (protein)	NP_000601 NP_001001389 NP_001001390 NP_001001391 NP_001001392 NP_001189484 NP_001189485 NP_001189486	NP_001034239 NP_001034240 NP_001171256 NP_001171257 NP_001171258 NP_033981
Location (UCSC)	Chr 11: 35.14 – 35.23 Mb	Chr 2: 102.81 – 102.9 Mb
PubMed search

1POZ, 1UUH, 2I83, 4PZ3, 4PZ4

960

12505

ENSG00000026508

ENSMUSG00000005087

P16070

P15379

NM_001202555
NM_001202556
NM_001202557

NM_009851

NP_001189484
NP_001189485
NP_001189486

NP_033981

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration. In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11. CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.

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Wikipedia