HAT1

HAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P0W
Identifiers
Aliases	HAT1, KAT1, histone acetyltransferase 1
External IDs	MGI: 96013 HomoloGene: 2701 GeneCards: HAT1
Gene ontology Molecular function • transferase activity • histone binding • H4 histone acetyltransferase activity • histone acetyltransferase activity • protein binding • transferase activity, transferring acyl groups Cellular component • cytoplasm • intracellular membrane-bounded organelle • nuclear matrix • nucleoplasm • protein complex • nuclear chromatin • nuclear chromosome, telomeric region • nucleus Biological process • response to nutrient • internal protein amino acid acetylation • DNA packaging • DNA replication-dependent nucleosome assembly • chromatin silencing at telomere • histone acetylation • histone H4 acetylation • DNA replication-independent nucleosome assembly • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8520	107435
Ensembl	ENSG00000128708	ENSMUSG00000027018
UniProt	O14929	Q8BY71
RefSeq (mRNA)	NM_001033085 NM_003642	NM_026115
RefSeq (protein)	NP_003633	NP_080391.2 NP_080391
Location (UCSC)	Chr 2: 171.92 – 171.98 Mb	Chr 2: 71.39 – 71.44 Mb
PubMed search

2P0W

8520

107435

ENSG00000128708

ENSMUSG00000027018

O14929

Q8BY71

NM_001033085
NM_003642

NM_026115

NP_003633

NP_080391.2
NP_080391

Histone acetyltransferase 1, also known as HAT1, is an enzyme that, in humans, is encoded by the HAT1 gene.

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.

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