HAPLN2

HAPLN2
Identifiers
Aliases	HAPLN2, BRAL1, hyaluronan and proteoglycan link protein 2
External IDs	MGI: 2137300 HomoloGene: 11045 GeneCards: HAPLN2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 156,619,294 bp End 156,625,725 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.78 cM Start 88,021,750 bp End 88,027,583 bp
Gene ontology Molecular function • hyaluronic acid binding • extracellular matrix structural constituent Cellular component • proteinaceous extracellular matrix • extracellular region Biological process • establishment of blood-nerve barrier • central nervous system development • extracellular matrix assembly • skeletal system development • cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60484	73940
Ensembl	ENSG00000132702	ENSMUSG00000004894
UniProt	Q9GZV7	Q9ESM3
RefSeq (mRNA)	NM_021817	NM_022031
RefSeq (protein)	NP_068589	NP_071314
Location (UCSC)	Chr 1: 156.62 – 156.63 Mb	Chr 1: 88.02 – 88.03 Mb
PubMed search

60484

73940

ENSG00000132702

ENSMUSG00000004894

Q9GZV7

Q9ESM3

NM_021817

NM_022031

NP_068589

NP_071314

Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a protein that in humans is encoded by the HAPLN2 gene.HAPLN1 codes for a related link protein that is expressed in cartilage while Bral1 is expressed in brain.

Bral1 interacts with versican and brevican in nodes of Ranvier. In mice with reduced Bralp1 expression the extracellular matrix at nodes of Ranvier is disrupted and action potential conduction is abnormal.

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