H2AFZ

H2AFZ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F66, 3WA9, 4CAY, 4NFT, 5FUG, 5CHL
Identifiers
Aliases	H2AFZ, H2A.Z-1, H2A.z, H2A/z, H2AZ, H2A histone family member Z
External IDs	MGI: 1888388 HomoloGene: 80218 GeneCards: H2AFZ
Gene ontology Molecular function • nucleosomal DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • chromatin DNA binding • protein binding • RNA polymerase II core promoter sequence-specific DNA binding • protein heterodimerization activity Cellular component • nuclear heterochromatin • nuclear euchromatin • nucleosome • extracellular exosome • Barr body • nucleus • chromosome Biological process • cellular response to estradiol stimulus • chromatin silencing • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3015	51788
Ensembl	ENSG00000164032	ENSMUSG00000037894
UniProt	P0C0S5	P0C0S6
RefSeq (mRNA)	NM_002106	NM_016750 NM_001316995
RefSeq (protein)	NP_002097	NP_058030.1 NP_001303924 NP_058030
Location (UCSC)	Chr 4: 99.95 – 99.95 Mb	Chr 3: 137.86 – 137.87 Mb
PubMed search

1F66, 3WA9, 4CAY, 4NFT, 5FUG, 5CHL

3015

51788

ENSG00000164032

ENSMUSG00000037894

P0C0S5

P0C0S6

NM_002106

NM_016750
NM_001316995

NP_002097

NP_058030.1
NP_001303924
NP_058030

Histone H2A.Z is a protein that in humans is encoded by the H2AFZ gene.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

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