H2AFY

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT

Identifiers

Aliases

H2AFY, H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2, H2A histone family member Y

External IDs

MGI: 1349392 HomoloGene: 3598 GeneCards: H2AFY

Gene ontology
Molecular function	• protein kinase binding • rDNA binding • protein serine/threonine kinase inhibitor activity • RNA polymerase II regulatory region sequence-specific DNA binding • chromatin binding • double-stranded methylated DNA binding • protein heterodimerization activity • RNA polymerase II core promoter sequence-specific DNA binding • transcription regulatory region DNA binding • core promoter sequence-specific DNA binding • DNA binding • chromatin DNA binding • enzyme binding • protein binding • nucleosomal DNA binding
Cellular component	• extracellular exosome • ESC/E(Z) complex • nucleolus • condensed chromosome • nuclear chromosome, telomeric region • chromosome • pericentric heterochromatin • nucleosome • nucleus • nuclear chromosome • sex chromatin • Barr body • nuclear chromatin • chromatin
Biological process	• chromatin silencing • negative regulation of histone H3-K4 methylation • regulation of chromatin silencing at rDNA • dosage compensation • negative regulation of cell cycle G2/M phase transition • positive regulation of gene expression, epigenetic • regulation of cell growth • positive regulation of keratinocyte differentiation • negative regulation of histone phosphorylation • negative regulation of protein serine/threonine kinase activity • negative regulation of transcription from RNA polymerase II promoter • nucleosome assembly • negative regulation of protein localization to chromosome, telomeric region • negative regulation of gene expression, epigenetic • negative regulation of histone H3-K27 methylation • regulation of gene expression, epigenetic • positive regulation of maintenance of mitotic sister chromatid cohesion • establishment of protein localization to chromatin • negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • regulation of lipid metabolic process • covalent chromatin modification • regulation of response to oxidative stress • negative regulation of response to oxidative stress • positive regulation of response to oxidative stress
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9555


26914

Ensembl


ENSG00000113648


ENSMUSG00000015937

UniProt


O75367


Q9QZQ8

RefSeq (mRNA)


NM_001040158 NM_004893 NM_138609 NM_138610


NM_001159513 NM_001159514 NM_001159515 NM_012015

RefSeq (protein)


NP_001035248 NP_004884 NP_613075 NP_613258

NP_001152985.1 NP_001152986.1 NP_001152987.1 NP_036145.1 NP_001152985
NP_001152986 NP_001152987 NP_036145

Location (UCSC)

Chr 5: 135.33 – 135.4 Mb

Chr 13: 56.07 – 56.14 Mb

PubMed search

1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT

NM_001040158
NM_004893
NM_138609
NM_138610

NM_001159513
NM_001159514
NM_001159515
NM_012015

...
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