Guillaume Philibert, 1st Count Duhesme (7 July 1766 in Mercurey (formerly Bourgneuf), Burgundy – 20 June 1815 near Waterloo) was a French general during the Napoleonic Wars.
Duhesme studied law and in 1792 was made colonel of a free corps by Charles-François Dumouriez, which he raised by his own means. As commander at Roermond, he held the post of Herstal, an important passage to the Netherlands, and burned the bridge of Leau after the defeat at Neerwinden on 18 March 1793. He then crossed the Schelde and at the Battle of Villeneuve rallied the fleeing infantry (6 July), for which action he was made brigadier general.
He also contributed greatly to the victory at the Fleurus on 26 July 1794 and besieged Maastricht under Kléber, and was promoted to general of division. He fought in the Vendée in 1795, and later at the Rhine, where he forced the passage over the river on 20 April 1797 below Kehl. In 1798 he was given a command in Italy under Championnet, participated at the siege of Naples and took control of Calabria and Apulia.