"Guess Things Happen That Way" is a 1958 cross over single by Johnny Cash, which was written by Jack Clement. The single, a song about "a man struggling ... after the love of his life has left him", was Johnny Cash's fourth number one on the country chart spending eight weeks at number one and a total of twenty-four weeks on the chart.

The B-side of "Guess Things Happen That Way", a song entitled, "Come In Stranger" made it to number six on the country chart. The single also crossed over to the pop chart, peaking at number eleven.

Pop singer June Valli had a minor revival of the song in 1961. Her version peaked at #92 in the Music Vendor Top 100.

On February 25, 2010, the song, purchased by grandfather and native Louie Sulcer, became the 10 billionth download through the Apple iTunes Store.

As Allmusic describes it, the song "featured an arrangement dominated by piano and a vocal chorus adding distinctive 'ba-doo's throughout [that is] ...slicker than, say, "Cry! Cry! Cry!" or "I Walk the Line" [but with] an eccentric tone all its own — largely because the vocal chorus (who sound as if they're occupying a middle ground between doo wop and barbershop quartet) is in such stark contrast to Cash's lead vocal."

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