Guanylate cyclase 2C

GUCY2C

Identifiers

GUCY2C, DIAR6, GUC2C, MECIL, MUCIL, STAR, guanylate cyclase 2C

External IDs

OMIM: 601330 MGI: 106903 HomoloGene: 3641 GeneCards: GUCY2C

Targeted by Drug

Gene ontology
Molecular function	• protein kinase activity • nucleotide binding • GTP binding • protein binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • ATP binding • toxic substance binding • guanylate cyclase activity
Cellular component	• integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • guanylate cyclase complex, soluble • plasma membrane
Biological process	• intracellular signal transduction • cyclic nucleotide biosynthetic process • receptor guanylyl cyclase signaling pathway • protein phosphorylation • regulation of cell proliferation • response to toxic substance • cGMP biosynthetic process • digestion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2984


14917

Ensembl


ENSG00000070019


ENSMUSG00000042638

UniProt


P25092


Q3UWA6

RefSeq (mRNA)


NM_004963


NM_001127318 NM_145067

RefSeq (protein)


NP_004954


NP_001120790.1 NP_659504.2 NP_001120790 NP_659504

Location (UCSC)

Chr 12: 14.61 – 14.7 Mb

Chr 6: 136.7 – 136.78 Mb

PubMed search

NM_001127318
NM_145067

NP_004954

NP_001120790.1
NP_659504.2
NP_001120790
NP_659504

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.

Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

...
Wikipedia