Growth hormone 2

GH2

Identifiers

GH2, GH-V, GHL, GHV, hGH-V, GHB2, Growth hormone 2

External IDs

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q23.3	Start	63,880,215 bp
Band	17q23.3	End	63,881,935 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• hormone activity
Cellular component	• extracellular region • endosome lumen
Biological process	• JAK-STAT cascade involved in growth hormone signaling pathway • regulation of receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2689


n/a

Ensembl


ENSG00000136487


n/a

UniProt


P01242


n/a

RefSeq (mRNA)


NM_022558 NM_002059 NM_022556 NM_022557


n/a

RefSeq (protein)


NP_002050 NP_072050 NP_072051 NP_072052


n/a

Location (UCSC)

Chr 17: 63.88 – 63.88 Mb

n/a

PubMed search

n/a

2689

n/a

ENSG00000136487

n/a

P01242

n/a

NM_022558
NM_002059
NM_022556
NM_022557

n/a

NP_002050
NP_072050
NP_072051
NP_072052

n/a

Growth hormone 2 (GH2), also known more commonly as placental growth hormone (PGH) or as growth hormone variant (GH-V), is a protein that in humans is encoded by the GH2 gene. It is produced by and secreted from the placenta during pregnancy, and becomes the predominant form of growth hormone (GH) in the body during this time. Its cogener is growth hormone 1 (GH1), or pituitary growth hormone.

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones, playing an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency.

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Wikipedia