Growth hormone-releasing hormone receptor

GHRHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDG
Identifiers
Aliases	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor
External IDs	OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR
Gene ontology Molecular function • G-protein coupled receptor activity • growth factor binding • signal transducer activity • peptide hormone binding • protein binding • growth hormone-releasing hormone receptor activity • transmembrane signaling receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • nuclear matrix • plasma membrane • secretory granule • cell surface • nuclear inner membrane • sarcolemma • nuclear outer membrane Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • determination of adult lifespan • positive regulation of cAMP metabolic process • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • response to glucocorticoid • cell maturation • adenohypophysis development • water homeostasis • activation of adenylate cyclase activity • response to estrogen • mammary gland development • response to insulin • positive regulation of circadian sleep/wake cycle, non-REM sleep • cell surface receptor signaling pathway • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of insulin-like growth factor receptor signaling pathway • growth hormone secretion • positive regulation of growth hormone secretion • positive regulation of cell proliferation • positive regulation of multicellular organism growth • cellular response to insulin stimulus • somatotropin secreting cell development • regulation of protein metabolic process • lactation • regulation of intracellular steroid hormone receptor signaling pathway • hormone metabolic process • positive regulation of hormone secretion • cAMP-mediated signaling • cellular response to glucose stimulus • signal transduction • multicellular organismal reproductive process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2692	14602
Ensembl	ENSG00000106128	ENSMUSG00000004654
UniProt	Q02643	P32082
RefSeq (mRNA)	NM_000823 NM_001009824	NM_001003685
RefSeq (protein)	NP_000814	NP_001003685.2 NP_001003685
Location (UCSC)	Chr 7: 30.94 – 30.99 Mb	Chr 6: 55.38 – 55.39 Mb
PubMed search

2XDG

2692

14602

ENSG00000106128

ENSMUSG00000004654

Q02643

P32082

NM_000823
NM_001009824

NM_001003685

NP_000814

NP_001003685.2
NP_001003685

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.

...
Wikipedia