Growth factor receptor-bound protein 2

GRB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW
Identifiers
Aliases	GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
External IDs	OMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2
Gene ontology Molecular function • protein domain specific binding • SH3 domain binding • protein kinase binding • identical protein binding • neurotrophin TRKA receptor binding • protein phosphatase binding • protein binding • ephrin receptor binding • SH3/SH2 adaptor activity • insulin receptor substrate binding • epidermal growth factor receptor binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphoprotein binding • enzyme binding • RNA binding • non-membrane spanning protein tyrosine kinase activity • phosphotyrosine residue binding Cellular component • extracellular exosome • nucleolus • cytoplasm • nucleoplasm • COP9 signalosome • Golgi apparatus • cytosol • nucleus • cell-cell junction • membrane • Grb2-EGFR complex • endosome • vesicle membrane • plasma membrane • protein complex • extrinsic component of cytoplasmic side of plasma membrane Biological process • T cell costimulation • Fc-gamma receptor signaling pathway involved in phagocytosis • branching involved in labyrinthine layer morphogenesis • MAPK cascade • phosphatidylinositol-mediated signaling • epidermal growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • insulin receptor signaling pathway • receptor internalization • cell-cell signaling • axon guidance • positive regulation of signal transduction • positive regulation of reactive oxygen species metabolic process • cellular response to ionizing radiation • Fc-epsilon receptor signaling pathway • viral process • positive regulation of actin filament polymerization • signal transduction in response to DNA damage • negative regulation of epidermal growth factor receptor signaling pathway • leukocyte migration • regulation of MAPK cascade • Ras protein signal transduction • anatomical structure formation involved in morphogenesis • positive regulation of GTPase activity • aging • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • protein heterooligomerization • entry of bacterium into host cell • membrane organization • cell migration • cell differentiation • peptidyl-tyrosine autophosphorylation • regulation of cell proliferation • innate immune response • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2885	14784
Ensembl	ENSG00000177885	ENSMUSG00000059923
UniProt	P62993	Q60631
RefSeq (mRNA)	NM_203506 NM_002086	NM_008163 NM_001313936 NM_001313937
RefSeq (protein)	NP_002077 NP_987102	NP_001300865 NP_001300866 NP_032189
Location (UCSC)	Chr 17: 75.32 – 75.41 Mb	Chr 11: 115.64 – 115.71 Mb
PubMed search

1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW

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