GroEL

HSPD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PJ1
Identifiers
Aliases	HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1
External IDs	OMIM: 118190 MGI: 96242 HomoloGene: 1626 GeneCards: HSPD1
Gene ontology Molecular function • nucleotide binding • chaperone binding • p53 binding • single-stranded DNA binding • ATPase activity • protein binding • double-stranded RNA binding • DNA replication origin binding • ATP binding • ubiquitin protein ligase binding • lipopolysaccharide binding • protein binding involved in protein folding • unfolded protein binding • RNA binding • hydrolase activity • protease binding • protein complex binding • insulin binding • protein heterodimerization activity • misfolded protein binding Cellular component • cytoplasm • cyclin-dependent protein kinase activating kinase holoenzyme complex • intracellular membrane-bounded organelle • myelin sheath • plasma membrane • secretory granule • protein complex • mitochondrial matrix • lipopolysaccharide receptor complex • early endosome • mitochondrion • mitochondrial inner membrane • clathrin-coated pit • coated vesicle • extracellular exosome • extracellular matrix • membrane • extracellular space • peroxisomal matrix • rough endoplasmic reticulum • Golgi apparatus • cytosol • cell surface • mitochondrial crista • zymogen granule • membrane raft Biological process • chaperone-mediated protein complex assembly • positive regulation of interleukin-12 production • positive regulation of interleukin-10 production • protein stabilization • protein maturation • positive regulation of macrophage activation • MyD88-dependent toll-like receptor signaling pathway • isotype switching to IgG isotypes • B cell activation • B cell cytokine production • response to unfolded protein • B cell proliferation • protein folding • positive regulation of T cell mediated immune response to tumor cell • protein refolding • positive regulation of interleukin-6 production • positive regulation of apoptotic process • response to cold • viral process • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of T cell activation • T cell activation • positive regulation of interferon-alpha production • positive regulation of interferon-gamma production • regulation of transcription from RNA polymerase II promoter • 'de novo' protein folding • protein import into mitochondrial intermembrane space • chaperone-mediated protein folding • response to hypoxia • detection of misfolded protein • response to ischemia • apoptotic mitochondrial changes • response to heat • response to organic substance • response to organic cyclic compound • response to activity • response to lipopolysaccharide • response to ATP • response to cocaine • response to drug • response to hydrogen peroxide • negative regulation of apoptotic process • negative regulation of neuron apoptotic process • response to estrogen • positive regulation of inflammatory response • chaperone mediated protein folding requiring cofactor • response to glucocorticoid • negative regulation of apoptotic process in bone marrow • negative regulation of reactive oxygen species biosynthetic process • positive regulation of tumor necrosis factor secretion • positive regulation of interleukin-6 secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3329	15510
Ensembl	ENSG00000144381	ENSMUSG00000025980
UniProt	P10809	P63038
RefSeq (mRNA)	NM_002156 NM_199440	NM_010477
RefSeq (protein)	NP_002147 NP_955472	NP_034607.3 NP_034607
Location (UCSC)	Chr 2: 197.49 – 197.52 Mb	Chr 1: 55.08 – 55.09 Mb
PubMed search

4PJ1

3329

15510

ENSG00000144381

ENSMUSG00000025980

P10809

P63038

NM_002156
NM_199440

NM_010477

NP_002147
NP_955472

NP_034607.3
NP_034607

GroEL belongs to the chaperonin family of molecular chaperones, and is found in a large number of bacteria. It is required for the proper folding of many proteins. To function properly, GroEL requires the lid-like cochaperonin protein complex GroES. In eukaryotes the proteins Hsp60 and Hsp10 are structurally and functionally nearly identical to GroEL and GroES, respectively.

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Wikipedia