Goncha Siso Enese is one of the woredas in the Amhara Region of Ethiopia. Part of the Misraq Gojjam Zone, Goncha Siso Enese is bordered on the south by Enarj Enawga, on the west by Hulet Ej Enese, on the north by the Abay River which separates it from the Debub Gondar Zone, and on the east by Enbise Sar Midir. The major town in Goncha Siso Enese is Ginde Weyin.
Rivers in this woreda include the Temmie, a tributary of the Abay.
In 2002, Goncha Siso Enese was judged to be one of four chronically food insecure woredas in this part of the Amhara Region, due to much of their farmland being "extremely depleted, deforested and eroded".
Based on the 2007 national census conducted by the Central Statistical Agency of Ethiopia (CSA), this woreda has a total population of 149,646, an increase of 29.66% over the 1994 census, of whom 74,347 are men and 75,299 women; 7,690 or 5.14% are urban inhabitants. With an area of 1,038.17 square kilometers, Goncha Siso Enese has a population density of 144.14, which is less than the Zone average of 153.8 persons per square kilometer. A total of 34,082 households were counted in this woreda, resulting in an average of 4.39 persons to a household, and 33,108 housing units. The majority of the inhabitants practiced Ethiopian Orthodox Christianity, with 98.99% reporting that as their religion.
The 1994 national census reported a total population for this woreda of 115,412 in 24,491 households, of whom 57,870 were men and 57,542 were women; 3,952 or 3.42% of its population were urban dwellers. The largest ethnic group reported in Goncha Siso Enese was the Amhara (99.97%). The majority of the inhabitants practiced Ethiopian Orthodox Christianity, with 98.08% reporting that as their religion, while 1.78% were Muslim.