"God in Me" is the second single released for Grammy Award-winning contemporary gospel group Mary Mary's fourth studio album The Sound, and featured Kierra Sheard. The single was written and produced by both Mary Mary and producer Warryn Campbell, husband of member Erica Campbell. The single is the group's first to chart on the Billboard Hot 100 since their debut single, "Shackles", charted in 2000. The song won Song of the Year at the 25th Annual Stellar Awards.

The music video for "God in Me" is about expressing individuality during a fashion show. It features appearances by Flex Alexander, Kanye West, Amber Rose, Common, Heavy D, and Fonzworth Bentley. America's Next Top Model, Cycle 11 runner-up Samantha Potter also made an appearance in the video. It ranked at #60 on BET's Notarized: Top 100 Videos of 2009 countdown.

The song has been a major success, and became the first song since their debut single "Shackles (Praise You)" to chart on the Billboard Hot 100 peaking at #68. So far the song has also spent 76 weeks on the Billboard Hot R&B/Hip-Hop Songs, and has currently peaked at #5. It reached the Top 10 of the chart in its 42nd week, the longest climb to the top tier in the survey's 67-year history. It also was the #1 for Hot Gospel Songs and Hot Dance Club Play charts. On May 20, 2009, "God in Me" broke the record for the longest-running hit for gospel female radio artist along with Mariah Carey's "We Belong Together" before being knocked off by Keyshia Cole's "Love" in 2006.

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