Glycoprotein VI

GP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GI7
Identifiers
Aliases	GP6, BDPLT11, GPIV, GPVI, glycoprotein VI platelet
External IDs	OMIM: 605546 MGI: 1889810 HomoloGene: 9488 GeneCards: GP6
Gene ontology Molecular function • protein binding • transmembrane signaling receptor activity • receptor activity • collagen binding Cellular component • integral component of membrane • cell surface • plasma membrane • tetraspanin-enriched microdomain • extracellular exosome • membrane • integral component of plasma membrane Biological process • platelet activation • hemostasis • blood coagulation • enzyme linked receptor protein signaling pathway • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51206	243816
Ensembl	n/a	ENSMUSG00000078810
UniProt	Q9HCN6	P0C191
RefSeq (mRNA)	NM_016363 NM_001083899 NM_001256017	NM_001163014
RefSeq (protein)	NP_001077368 NP_001242946 NP_057447	NP_001156486.1 NP_001156486
Location (UCSC)	Chr 19: 55.01 – 55.04 Mb	Chr 7: 4.36 – 4.4 Mb
PubMed search

2GI7

51206

243816

n/a

ENSMUSG00000078810

Q9HCN6

P0C191

NM_016363
NM_001083899
NM_001256017

NM_001163014

NP_001077368
NP_001242946
NP_057447

NP_001156486.1
NP_001156486

Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In humans, glycoprotein VI is encoded by the GPVI gene.

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke.

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Wikipedia