Glyceraldehyde-3-phosphate dehydrogenase

GAPDH

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1U8F, 1ZNQ, 3GPD, 4WNC, 4WNI

Identifiers

Aliases

GAPDH, GAPD, G3PD, HEL-S-162eP, glyceraldehyde-3-phosphate dehydrogenase

External IDs

OMIM: 138400 MGI: 95640 HomoloGene: 107053 GeneCards: GAPDH

Gene ontology
Molecular function	• transferase activity • microtubule binding • NAD binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • protein binding • peptidyl-cysteine S-nitrosylase activity • NADP binding • identical protein binding • oxidoreductase activity • glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity • aspartic-type endopeptidase inhibitor activity • disordered domain specific binding
Cellular component	• vesicle • nuclear membrane • membrane • intracellular membrane-bounded organelle • microtubule cytoskeleton • lipid droplet • plasma membrane • intracellular ribonucleoprotein complex • perinuclear region of cytoplasm • GAIT complex • cytoskeleton • extracellular exosome • cytosol • Q40260 • extracellular matrix • cytoplasm
Biological process	• peptidyl-cysteine S-trans-nitrosylation • neuron apoptotic process • gluconeogenesis • negative regulation of translation • glycolytic process • canonical glycolysis • protein stabilization • cellular response to interferon-gamma • oxidation-reduction process • regulation of translation • microtubule cytoskeleton organization • regulation of macroautophagy • apoptotic process • glucose metabolic process • negative regulation of endopeptidase activity • killing of cells of other organism • positive regulation of cytokine secretion • defense response to fungus • killing by host of symbiont cells • positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction • antimicrobial humoral immune response mediated by antimicrobial peptide
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2597


14433

Ensembl


ENSG00000111640


ENSMUSG00000057666

UniProt


P04406


P16858

RefSeq (mRNA)


NM_002046 NM_001256799 NM_001289745 NM_001289746


NM_008084 NM_001289726

RefSeq (protein)


NP_001243728 NP_001276674 NP_001276675 NP_002037


NP_001276655 NP_032110

Location (UCSC)

Chr 12: 6.53 – 6.54 Mb

Chr 6: 125.16 – 125.17 Mb

PubMed search

Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

determinants of enzyme thermostability observed in the molecular structure of thermus aquaticus d-glyceraldehyde-3-phosphate dehydrogenase at 2.5 angstroms resolution

Identifiers

Symbol

Gp_dh_N

Pfam clan