Glucocerebrosidase

GBA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OGS, 1Y7V, 2F61, 2J25, 2NSX, 2NT0, 2NT1, 2V3D, 2V3E, 2V3F, 2VT0, 2WCG, 2WKL, 2XWD, 2XWE, 3GXD, 3GXF, 3GXI, 3GXM, 3KE0, 3KEH, 3RIK, 3RIL
Identifiers
Aliases	GBA, GBA1, GCB, GLUC, glucosylceramidase beta, Glucocerebrosidase
External IDs	OMIM: 606463 MGI: 95665 HomoloGene: 68040 GeneCards: GBA
Gene ontology Molecular function • hydrolase activity, acting on glycosyl bonds • protein binding • hydrolase activity • receptor binding • glucosylceramidase activity Cellular component • membrane • lysosome • extracellular exosome • lysosomal lumen • lysosomal membrane • extracellular space Biological process • termination of signal transduction • skin morphogenesis • glycosphingolipid metabolic process • positive regulation of protein dephosphorylation • lipid metabolic process • response to testosterone • cellular response to starvation • negative regulation of interleukin-6 production • response to thyroid hormone • ceramide biosynthetic process • cellular response to tumor necrosis factor • sphingosine biosynthetic process • positive regulation of proteolysis involved in cellular protein catabolic process • response to glucocorticoid • regulation of water loss via skin • response to estrogen • glucosylceramide catabolic process • negative regulation of MAP kinase activity • response to pH • metabolic process • negative regulation of inflammatory response • regulation of macroautophagy • sphingolipid metabolic process • mitochondrion organization • neuron projection development • regulation of cellular protein metabolic process • negative regulation of cellular protein metabolic process • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of protein homooligomerization • cell death in response to oxidative stress • positive regulation of protein complex disassembly • regulation of protein metabolic process • positive regulation of protein metabolic process • negative regulation of neuron death • positive regulation of protein lipidation • positive regulation of neuronal action potential • positive regulation of mitophagy in response to mitochondrial depolarization • autophagosome organization • regulation of lysosomal protein catabolic process • beta-glucoside catabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2629	14466
Ensembl	n/a	ENSMUSG00000028048
UniProt	P04062	P17439
RefSeq (mRNA)	NM_000157 NM_001005741 NM_001005742 NM_001005749 NM_001005750 NM_001171811 NM_001171812	NM_001077411 NM_008094
RefSeq (protein)	NP_000148 NP_001005741 NP_001005742 NP_001165282 NP_001165283	NP_001070879.1 NP_032120.1 NP_001070879 NP_032120
Location (UCSC)	Chr 1: 155.23 – 155.24 Mb	Chr 3: 89.2 – 89.21 Mb
PubMed search

1OGS, 1Y7V, 2F61, 2J25, 2NSX, 2NT0, 2NT1, 2V3D, 2V3E, 2V3F, 2VT0, 2WCG, 2WKL, 2XWD, 2XWE, 3GXD, 3GXF, 3GXI, 3GXM, 3KE0, 3KEH, 3RIK, 3RIL

2629

14466

n/a

...
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