Glial fibrillary acidic protein

GFAP
Identifiers
Aliases	GFAP, ALXDRD, glial fibrillary acidic protein
External IDs	OMIM: 137780 MGI: 95697 HomoloGene: 1554 GeneCards: GFAP
Gene ontology Molecular function • structural molecule activity • protein binding • identical protein binding • structural constituent of cytoskeleton Cellular component • cytoplasm • cytosol • lysosome • intermediate filament cytoskeleton • intermediate filament Biological process • regulation of protein complex assembly • cytoskeleton organization • regulation of chaperone-mediated autophagy Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2670	14580
Ensembl	ENSG00000131095	ENSMUSG00000020932
UniProt	P14136	P14136 P03995
RefSeq (mRNA)	NM_002055 NM_001131019 NM_001242376	NM_001131020 NM_010277
RefSeq (protein)	NP_001124491 NP_001229305 NP_002046	NP_001124491 NP_001229305 NP_002046 NP_001124492.1 NP_034407.2 NP_001124492 NP_034407
Location (UCSC)	Chr 17: 44.91 – 44.92 Mb	Chr 11: 102.89 – 102.9 Mb
PubMed search

2670

14580

ENSG00000131095

ENSMUSG00000020932

P14136

P14136
P03995

NM_002055
NM_001131019
NM_001242376

NM_001131020
NM_010277

NP_001124491
NP_001229305
NP_002046

NP_001124492
NP_034407

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans.

Glial fibrillary acidic protein is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes and ependymal cells. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneysLeydig cells of the testis in both hamsters and humans, human keratinocytes, human osteocytes and chondrocytes and stellate cells of the pancreas and liver in rats. First described in 1971, GFAP is a type III IF protein that maps, in humans, to 17q21. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells but its exact function remains poorly understood, despite the number of studies using it as a cell marker. Glial fibrillary acidic protein (GFAP) was named and first isolated and characterized by Lawrence F. Eng in 1969.

...
Wikipedia