"Give It 2 Me" is a song by American singer and songwriter Madonna, featured on her 11th studio album Hard Candy. It was released on June 24, 2008 by Warner Bros. Records as the second single from the album. The song was written by Madonna as an anthemic, self-manifesto song which, although it appears to be about dance and sex, is a reference to Madonna's career spanning three decades in the music industry. Musically, "Give It 2 Me" is an upbeat dance-pop song, featuring instrumentation from West African percussion and cowbells. Backing vocals are provided by Pharrell Williams.

"Give It 2 Me" received positive reviews from contemporary critics. The song became Madonna's 39th number-one single on the Billboard Hot Dance Club Play chart. It charted on the Billboard Hot 100 for one week, and reached a peak of 57 only, due to limited radio play. The song topped the music charts in Hungary, the Netherlands and Spain, while it peaked within the top ten of the charts in many other nations, including Canada, Denmark and the United Kingdom.

The music video featured Madonna recreating her look from the Elle magazine May covergirl photo shoot, and was directed by photographer Tom Munro. Williams had a guest appearance in the video. It received positive response for her retro-inspired look. Madonna performed "Give It 2 Me" on both the promotional tour for Hard Candy, and the 2008–09 Sticky & Sweet Tour. The song was additionally performed at a special concert for The MDNA Tour at Madison Square Garden in 2012. "Give It 2 Me" received a Grammy nomination in 2009 in the Best Dance Recording category.

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