A German mission was established in Onondaga County, New York in 1750, by Moravian missionaries from Pennsylvania, however, most of the earliest Germans to arrive in the area did not remain for very long.
The German immigrants who first settled in the farmlands around Syracuse beginning in the early 19th century came from all areas of Germany including Alsace which was then a part of France. During the 1820s and 1830s, most came from Southern Germany, namely: Baden, Bavaria, Hesse-Darmstadt and Württemberg which were the areas devastated by the Napoleonic War, among others. The arrivals from Northern Germany including Franconia, Lorraine and Prussia came later
By 2010, demographics showed that 12.2% of the population in Syracuse was of German descent.
During 1750, the Moravian brothers arrived in Onondaga, the "chief town of the Six Nations", situated in Central New York, which contained five small towns and villages situated next to the River Zinochsaa. The missionaries were lodged at the house of the chief, who welcomed them with much cordiality. The object of this visit was both to fulfill the promise of a visit to the great Council of the Iroquois made in 1749 to the deputies at Philadelphia, Pennsylvania, and to obtain permission for members of the missionary to live either at Onondaga or some other town of the Iroquois in order to learn the language and to "preach the gospel." The mission stayed for six years, however, with no clear result.