Georges d'Amboise (1460 – May 25, 1510) was a French Roman Catholic cardinal and minister of state. He belonged to the house of Amboise, a noble family possessed of considerable influence: of his nine brothers, four were bishops. His father, Pierre d'Amboise, seigneur de Chaumont, was chamberlain to Charles VII and Louis XI and ambassador at Rome. Georges' eldest brother, Charles, was governor of the Île-de-France, Champagne and Burgundy, and councillor of Louis XI.
Georges d'Amboise was born at the family castle in Chaumont-sur-Loire.
He was only fourteen when his father procured for him the bishopric of Montauban, and Louis XI appointed him one of his almoners. On arriving at manhood d'Amboise attached himself to the party of Louis, duc d'Orléans, in whose cause he suffered imprisonment at Corbeil, and on whose return to the royal favor he was elevated to the archbishopric of Narbonne, (June 18, 1482) in which the pope refused to confirm him; after some time he changed his see for that of Rouen (1493). On the appointment of Orléans as governor of Normandy, d'Amboise became his lieutenant-general.
In 1498 the duc d'Orléans mounted the throne as Louis XII, and d'Amboise was suddenly raised to the high position of cardinal (September 17, 1498) and prime minister. In December 1498, he obtained, for reasons of state, the annulment of the marriage of the king to Jeanne de Valois; the king married Anne de Bretagne, widow of the king, in January 1499.