George Douglas of Pittendreich (died 1552) was a member of the powerful Red Douglas family who struggled for control of the young James V of Scotland in 1528. His second son became James Douglas, 4th Earl of Morton and Regent of Scotland. Initially, George Douglas promoted the marriage of Mary, Queen of Scots and Prince Edward of England. After war was declared between England and Scotland he worked for peace and to increase the power of Mary of Guise, the widow of James V.
George Douglas was the brother of Archibald Douglas, 6th Earl of Angus, and so was called 'Master of Angus' in his lifetime. His parents were George Douglas, Master of Angus, and Elizabeth Drummond, daughter of John Drummond, 1st Lord Drummond. The Douglas family gained custody of the young James V in 1526. After the king escaped from them, and laid siege to Tantallon Castle in 1529, the family members and allies were forfeited of their lands and titles by the Parliament of Scotland.
George had married Elizabeth Douglas, the daughter and heir of David Douglas of Pittendreich near Elgin. When the Douglases were re-instated in 1543, Pittendreich was the legal representative of the Earl of Morton whose lands were also forfeited. When the Morton lands were restored, George married his son James, the future Regent, to Morton's youngest daughter, Elizabeth Douglas. The 3rd Earl of Morton's eldest daughter Margaret married James Hamilton, 2nd Earl of Arran and another daughter married Lord Maxwell. Sadly, these three sisters were all affected by mental ill-health.