Gastric inhibitory polypeptide receptor

GIPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HJ0, 2QKH
Identifiers
Aliases	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs	OMIM: 137241 MGI: 1352753 HomoloGene: 20081 GeneCards: GIPR
Genetically Related Diseases
obesity
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • peptide hormone binding • gastric inhibitory peptide receptor activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • plasma membrane Biological process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • response to fatty acid • response to nutrient • regulation of insulin secretion • positive regulation of cytosolic calcium ion concentration • response to glucose • generation of precursor metabolites and energy • activation of adenylate cyclase activity • response to calcium ion • cell surface receptor signaling pathway • gastric inhibitory peptide signaling pathway • response to axon injury • desensitization of G-protein coupled receptor protein signaling pathway • endocrine pancreas development • signal transduction • positive regulation of insulin secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2696	381853
Ensembl	ENSG00000010310	ENSMUSG00000030406
UniProt	P48546	Q0P543
RefSeq (mRNA)	NM_000164 NM_001308418	NM_001080815
RefSeq (protein)	NP_000155 NP_001295347	NP_001074284.1 NP_001074284
Location (UCSC)	Chr 19: 45.67 – 45.68 Mb	Chr 7: 19.16 – 19.17 Mb
PubMed search

4HJ0, 2QKH

2696

381853

ENSG00000010310

ENSMUSG00000030406

P48546

Q0P543

NM_000164
NM_001308418

NM_001080815

NP_000155
NP_001295347

NP_001074284.1
NP_001074284

The gastric inhibitory polypeptide receptor (GIP-R) also known as the glucose-dependent insulinotropic polypeptide receptor is a protein that in humans is encoded by the GIPR gene. The GIP-R is seven-transmembrane proteins found on beta-cells in the pancreas.

Gastric inhibitory polypeptide (GIP), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.

...
Wikipedia