Gap-43 protein

GAP43
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4E53
Identifiers
Aliases	GAP43, B-50, PP46, growth associated protein 43
External IDs	OMIM: 162060 MGI: 95639 HomoloGene: 1545 GeneCards: GAP43
Gene ontology Molecular function • lysophosphatidic acid binding • phosphatidylinositol phosphate binding • phosphatidylserine binding • calmodulin binding • protein binding Cellular component • cytoplasm • cell projection • membrane • postsynaptic density • growth cone membrane • synapse • axon • cell junction • cell periphery • filopodium membrane • plasma membrane Biological process • regulation of filopodium assembly • cell differentiation • cell fate commitment • tissue regeneration • glial cell differentiation • nervous system development • multicellular organism development • protein kinase C-activating G-protein coupled receptor signaling pathway • response to wounding • regulation of growth • axon choice point recognition • axon development • axon guidance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2596	14432
Ensembl	ENSG00000172020	ENSMUSG00000047261
UniProt	P17677	P06837
RefSeq (mRNA)	NM_002045 NM_001130064	NM_008083
RefSeq (protein)	NP_001123536 NP_002036	NP_032109.1 NP_032109
Location (UCSC)	Chr 3: 115.62 – 115.72 Mb	Chr 16: 42.25 – 42.34 Mb
PubMed search

4E53

2596

14432

ENSG00000172020

ENSMUSG00000047261

P17677

P06837

NM_002045
NM_001130064

NM_008083

NP_001123536
NP_002036

NP_032109.1
NP_032109

Growth Associated Protein 43 also known as GAP43 is a protein that in humans is encoded by the GAP43 gene.

GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development, during axonal regeneration and is phosphorylated after long-term potentiation (LTP) and after learning (reference needed). This protein is considered a crucial component of the axon and presynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.

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