Gamma-synuclein

SNCG
Identifiers
Aliases	SNCG, BCSG1, SR, synuclein gamma
External IDs	MGI: 1298397 HomoloGene: 2322 GeneCards: SNCG
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • microtubule organizing center • perinuclear region of cytoplasm • axon • neuronal cell body • spindle • extracellular exosome • cytoskeleton Biological process • protein secretion • adult locomotory behavior • regulation of dopamine secretion • synapse organization • regulation of neurotransmitter secretion • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6623	20618
Ensembl	ENSG00000173267	ENSMUSG00000023064
UniProt	O76070	Q9Z0F7
RefSeq (mRNA)	NM_003087 NM_001330120	NM_011430
RefSeq (protein)	NP_001317049 NP_003078	NP_035560.1 NP_035560
Location (UCSC)	Chr 10: 86.96 – 86.96 Mb	Chr 14: 34.37 – 34.37 Mb
PubMed search

6623

20618

ENSG00000173267

ENSMUSG00000023064

O76070

Q9Z0F7

NM_003087
NM_001330120

NM_011430

NP_001317049
NP_003078

NP_035560.1
NP_035560

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.

Synuclein-gamma is a member of the synuclein family of proteins, which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development. Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. It is also detected in the brain, ovarian tumors, and in the olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins.

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