Gabriel von Salamanca-Ortenburg (1489 – 12 December 1539) was a Spanish nobleman who was general treasurer and archchancellor of the Habsburg archduke (and future Holy Roman Emperor) Ferdinand I of Austria from 1521 to 1526.
Descending from a wealthy merchant family in Burgos in Castile, Gabriel von Salamanca in 1514 was already chancellor under the Habsburg emperor Maximilian I, who had forged an alliance with King Ferdinand II of Aragon and Queen Isabella I of Castile by marrying his son Philip the Handsome off to their daughter Joanna.
In this period Salamanca made friends with Maximilian's grandson Archduke Ferdinand I, who after the emperor's death in 1519 received the Habsburg hereditary lands of Austria with the duchies of Styria, Carinthia and Carniola (then called "Inner Austria") as well as Tyrol and Further Austria from his elder brother Emperor Charles V in 1521. Gabriel acted as Ferdinand's treasurer and archchancellor; his economic measures however ultimatively failed as his purported self-serving manners met with fierce opposition by the Austrian and Tyrolean aristocracy, who called him an "archarian jew" and "stinking heretic".
In 1523 he was elevated to the rank of an Imperial Freiherr (Baron) and Lord of Ehrenberg Castle in Tyrol as well as of Freyenstein and Karlsbach in Austria. On 10 March 1524 he further received the possessions of the extinct Counts of Ortenburg in Carinthia, which were last held by Count Ulrich II of Celje, together with the Ortenburg comital title, which earned him the enmity of the Bavarian Ortenburg dynasty.