Gabre

GABRE

Identifiers

External IDs

Targeted by Drug

Gene ontology
Molecular function	• chloride channel activity • extracellular ligand-gated ion channel activity • GABA-gated chloride ion channel activity • GABA-A receptor activity
Cellular component	• integral component of membrane • cell junction • postsynaptic membrane • plasma membrane • synapse • membrane • chloride channel complex • GABA-A receptor complex
Biological process	• ion transmembrane transport • chloride transport • chloride transmembrane transport • ion transport • negative regulation of chloride transport • signal transduction • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2564


n/a

Ensembl


ENSG00000102287


n/a

UniProt


P78334


n/a

RefSeq (mRNA)


NM_004961 NM_021984 NM_021987 NM_021990


n/a

RefSeq (protein)


NP_004952


n/a

Location (UCSC)

Chr X: 151.95 – 151.97 Mb

n/a

PubMed search

n/a

2564

n/a

ENSG00000102287

n/a

P78334

n/a

NM_004961
NM_021984
NM_021987
NM_021990

n/a

NP_004952

n/a

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.

Brainstem expression of ε subunit-containing GABA_A receptors is upregulated during pregnancy, particularly in the ventral respiratory group.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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