GYPA

GYPA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1AFO, 2KPE, 2KPF, 5EH4, 5EH6
Identifiers
Aliases	GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2, glycophorin A (MNS blood group)
External IDs	HomoloGene: 48076 GeneCards: GYPA
Gene ontology Molecular function • identical protein binding • virus receptor activity Cellular component • integral component of membrane • plasma membrane • extracellular exosome • membrane Biological process • viral entry into host cell • viral process • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2993	n/a
Ensembl	ENSG00000170180	n/a
UniProt	P02724	n/a
RefSeq (mRNA)	NM_001308187 NM_001308190 NM_002099	n/a
RefSeq (protein)	NP_001295116 NP_001295119 NP_002090	n/a
Location (UCSC)	Chr 4: 144.11 – 144.14 Mb	n/a
PubMed search		n/a

1AFO, 2KPE, 2KPF, 5EH4, 5EH6

2993

n/a

ENSG00000170180

n/a

P02724

n/a

NM_001308187
NM_001308190
NM_002099

n/a

NP_001295116
NP_001295119
NP_002090

n/a

Glycophorin A (MNS blood group), also known as GYPA, is a protein which in humans is encoded by the GYPA gene. GYPA has also recently been designated CD235a (cluster of differentiation 235a).

Glycophorins A (GYPA; this protein) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.

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