GUCY1B3

GUCY1B3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WZ1, 3UVJ, 4NI2
Identifiers
Aliases	GUCY1B3, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B1, guanylate cyclase 1, soluble, beta 3, guanylate cyclase 1 soluble subunit beta
External IDs	MGI: 1860604 HomoloGene: 664 GeneCards: GUCY1B3
Gene ontology Molecular function • nucleotide binding • guanylate cyclase activity • GTP binding • metal ion binding • protein binding • heme binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • receptor activity Cellular component • plasma membrane • guanylate cyclase complex, soluble • cytoplasm Biological process • intracellular signal transduction • cyclic nucleotide biosynthetic process • blood circulation • nitric oxide-cGMP-mediated signaling pathway • cGMP biosynthetic process • nitric oxide mediated signal transduction • cellular response to nitric oxide Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2983	54195
Ensembl	ENSG00000061918	ENSMUSG00000028005
UniProt	Q02153	O54865
RefSeq (mRNA)	NM_000857 NM_001291951 NM_001291952 NM_001291953 NM_001291954 NM_001291955	NM_001161796 NM_017469
RefSeq (protein)	NP_000848 NP_001278880 NP_001278881 NP_001278882 NP_001278883 NP_001278884	NP_059497.1 NP_001155268 NP_059497
Location (UCSC)	Chr 4: 155.76 – 155.81 Mb	Chr 3: 82.03 – 82.07 Mb
PubMed search

2WZ1, 3UVJ, 4NI2

2983

54195

ENSG00000061918

ENSMUSG00000028005

Q02153

O54865

NM_001291955

NM_001161796
NM_017469

NP_001278884

NP_059497.1
NP_001155268
NP_059497

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.

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Wikipedia