GUCY1A3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3UVJ, 4NI2

Identifiers

GUCY1A3, GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A1, MYMY6, guanylate cyclase 1, soluble, alpha 3, guanylate cyclase 1 soluble subunit alpha

External IDs

Gene ontology
Molecular function	• nucleotide binding • guanylate cyclase activity • GTP binding • protein binding • heme binding • lyase activity • adenylate cyclase activity • phosphorus-oxygen lyase activity • receptor activity
Cellular component	• cytoplasm • plasma membrane • guanylate cyclase complex, soluble
Biological process	• intracellular signal transduction • cyclic nucleotide biosynthetic process • positive regulation of cGMP biosynthetic process • blood circulation • regulation of blood pressure • cGMP biosynthetic process • relaxation of vascular smooth muscle • response to defense-related host nitric oxide production • nitric oxide mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2982


60596


ENSG00000164116


ENSMUSG00000033910


Q02108 Q6PJR4


Q9ERL9

RefSeq (mRNA)

NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685
NM_001130686 NM_001130687 NM_001256449


NM_021896

RefSeq (protein)

NP_000847 NP_001124154 NP_001124155 NP_001124156 NP_001124157
NP_001124159 NP_001243378


NP_068696.2 NP_068696

Location (UCSC)

PubMed search

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs. Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).