GSK-3β

GSK3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN
Identifiers
Aliases	GSK3B, Gsk3b, 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3, glycogen synthase kinase 3 beta
External IDs	MGI: 1861437 HomoloGene: 55629 GeneCards: GSK3B
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 3 (human) Band 3q13.33 Start 119,821,323 bp End 120,094,417 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 38,089,001 bp End 38,246,084 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • kinase activity • ATP binding • protein kinase activity • protein kinase A catalytic subunit binding • protein serine/threonine kinase activity • transferase activity • RNA polymerase II transcription factor binding • NF-kappaB binding • tau-protein kinase activity • protein binding • nucleotide binding • p53 binding • ubiquitin protein ligase binding • protease binding • beta-catenin binding • protein kinase binding Cellular component • cytoplasm • membrane • mitochondrion • cell nucleus • centrosome • plasma membrane • cytosol • beta-catenin destruction complex • postsynapse • Wnt signalosome Biological process • rhythmic process • negative regulation of type B pancreatic cell development • negative regulation of protein binding • negative regulation of glycogen (starch) synthase activity • glycogen metabolic process • superior temporal gyrus development • negative regulation of canonical Wnt signaling pathway • chemical synaptic transmission, postsynaptic • negative regulation of protein complex assembly • positive regulation of protein export from nucleus • positive regulation of GTPase activity • protein autophosphorylation • cell differentiation • negative regulation of protein localization to nucleus • phosphorylation • positive regulation of cell-matrix adhesion • nervous system development • dopamine receptor signaling pathway • epithelial to mesenchymal transition • peptidyl-threonine phosphorylation • positive regulation of protein complex assembly • positive regulation of neuron death • negative regulation of glycogen biosynthetic process • multicellular organism development • negative regulation of NFAT protein import into nucleus • regulation of cellular response to heat • negative regulation of signal transduction • hippocampus development • beta-catenin destruction complex disassembly • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • beta-catenin destruction complex assembly • protein phosphorylation • positive regulation of mitochondrion organization • intracellular signal transduction • positive regulation of protein catabolic process • negative regulation of dopaminergic neuron differentiation • ER overload response • circadian rhythm • peptidyl-serine phosphorylation • positive regulation of protein binding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • regulation of microtubule-based process • cellular response to interleukin-3 • negative regulation of apoptotic process • canonical Wnt signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • carbohydrate metabolic process • neuron projection development • negative regulation of neuron death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2932	56637
Ensembl	ENSG00000082701	ENSMUSG00000022812
UniProt	P49841	Q9WV60
RefSeq (mRNA)	NM_001146156 NM_002093 NM_001354596	NM_019827 NM_001347232
RefSeq (protein)	NP_001139628 NP_002084 NP_001341525	NP_001334161 NP_062801
Location (UCSC)	Chr 3: 119.82 – 120.09 Mb	Chr 16: 38.09 – 38.25 Mb
PubMed search

1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN

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