GRIK3

GRIK3
Identifiers
Aliases	GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a, glutamate ionotropic receptor kainate type subunit 3
External IDs	MGI: 95816 HomoloGene: 73901 GeneCards: GRIK3
Gene ontology Molecular function • kainate selective glutamate receptor activity • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity • ion channel activity • extracellular-glutamate-gated ion channel activity • receptor activity • ligand-gated ion channel activity • ionotropic glutamate receptor activity • G-protein coupled receptor binding • glutamate receptor activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • cell junction • dendrite cytoplasm • perikaryon • dendrite • terminal bouton • axon Biological process • G-protein coupled glutamate receptor signaling pathway • glutamate receptor signaling pathway • ion transport • ion transmembrane transport • transport • negative regulation of synaptic transmission, glutamatergic • ionotropic glutamate receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • regulation of membrane potential • excitatory postsynaptic potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2899	14807
Ensembl	ENSG00000163873	ENSMUSG00000001985
UniProt	Q13003	B1AS29
RefSeq (mRNA)	NM_000831	NM_001081097
RefSeq (protein)	NP_000822	NP_001074566.1 NP_001074566
Location (UCSC)	Chr 1: 36.8 – 37.03 Mb	Chr 4: 125.49 – 125.71 Mb
PubMed search

2899

14807

ENSG00000163873

ENSMUSG00000001985

Q13003

B1AS29

NM_000831

NM_001081097

NP_000822

NP_001074566.1
NP_001074566

Glutamate receptor, ionotropic kainate 3 is a protein that in humans is encoded by the GRIK3 gene.

This gene encodes a protein that belongs to the ligand-gated ionic channel family. It can coassemble with either GRIK4 or GRIK5 to form heteromeric receptors and acts as an excitatory neurotransmitter at many synapses in the central nervous system. RNA editing in the mRNA has been reported.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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