GRIA1

GRIA1
Identifiers
Aliases	GRIA1, GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate ionotropic receptor AMPA type subunit 1, Glutamate receptor, ionotropic, AMPA 1
External IDs	MGI: 95808 HomoloGene: 20226 GeneCards: GRIA1
Gene ontology Molecular function • glutamate receptor activity • PDZ domain binding • AMPA glutamate receptor activity • ion channel activity • protein binding • ionotropic glutamate receptor activity • extracellular-glutamate-gated ion channel activity • receptor activity • excitatory extracellular ligand-gated ion channel activity • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component • integral component of membrane • recycling endosome • endocytic vesicle membrane • postsynaptic membrane • cell projection • endoplasmic reticulum membrane • membrane • synaptic vesicle • postsynaptic density • axonal spine • plasma membrane • dendritic spine • synapse • dendrite membrane • cell surface • cell junction • neuronal cell body • dendrite • endoplasmic reticulum • dendritic spine membrane • neuron spine • ER to Golgi transport vesicle membrane • neuron projection • AMPA glutamate receptor complex • ionotropic glutamate receptor complex • endoplasmic reticulum-Golgi intermediate compartment membrane • Golgi membrane • postsynapse • postsynaptic density membrane Biological process • receptor internalization • ion transport • ER to Golgi vesicle-mediated transport • ion transmembrane transport • COPII vesicle coating • long-term memory • transport • long term synaptic depression • signal transduction • chemical synaptic transmission • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • regulation of postsynaptic membrane potential • regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2890	14799
Ensembl	ENSG00000155511	ENSMUSG00000020524
UniProt	P42261	P23818
RefSeq (mRNA)	NM_000827 NM_001114183 NM_001258019 NM_001258020 NM_001258021 NM_001258022 NM_001258023	NM_001113325 NM_001252403 NM_008165
RefSeq (protein)	NP_000818 NP_001107655 NP_001244948 NP_001244949 NP_001244950 NP_001244951 NP_001244952	NP_001106796.1 NP_001106796 NP_001239332 NP_032191
Location (UCSC)	Chr 5: 153.49 – 153.81 Mb	Chr 11: 57.01 – 57.33 Mb
PubMed search

2890

14799

ENSG00000155511

ENSMUSG00000020524

P42261

P23818

NM_001258022
NM_001258023

NM_001113325
NM_001252403
NM_008165

NP_001244951
NP_001244952

NP_001106796.1
NP_001106796
NP_001239332
NP_032191

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.

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Wikipedia