GRHPR

GRHPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GCG, 2H1S, 2Q50, 2WWR
Identifiers
Aliases	GRHPR, GLXR, GLYD, PH2, glyoxylate reductase/hydroxypyruvate reductase
External IDs	MGI: 1923488 HomoloGene: 49088 GeneCards: GRHPR
Gene ontology Molecular function • glycerate dehydrogenase activity • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • protein homodimerization activity • NAD binding • carboxylic acid binding • NADP binding • NADPH binding • oxidoreductase activity • hydroxypyruvate reductase activity • glyoxylate reductase (NADP) activity Cellular component • cytoplasm • peroxisomal matrix • extracellular exosome • cytosol Biological process • dicarboxylic acid metabolic process • excretion • glyoxylate metabolic process • protein oligomerization • metabolic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9380	76238
Ensembl	ENSG00000137106	ENSMUSG00000035637
UniProt	Q9UBQ7	Q91Z53
RefSeq (mRNA)	NM_012203	NM_080289 NM_001312880
RefSeq (protein)	NP_036335	NP_525028.1 NP_001299809 NP_525028
Location (UCSC)	Chr 9: 37.42 – 37.44 Mb	Chr 4: 44.98 – 44.99 Mb
PubMed search

2GCG, 2H1S, 2Q50, 2WWR

9380

76238

ENSG00000137106

ENSMUSG00000035637

Q9UBQ7

Q91Z53

NM_012203

NM_080289
NM_001312880

NP_036335

NP_525028.1
NP_001299809
NP_525028

Glyoxylate reductase/hydroxypyruvate reductase is an enzyme that in humans is encoded by the GRHPR gene.

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.

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Wikipedia