GPR99

OXGR1
Identifiers
Aliases	OXGR1, GPR80, GPR99, P2RY15, P2Y15, aKGR, oxoglutarate receptor 1
External IDs	MGI: 2685145 HomoloGene: 25878 GeneCards: OXGR1
Targeted by Drug
oxogluric acid
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27199	239283
Ensembl	ENSG00000165621	ENSMUSG00000044819
UniProt	Q96P68	Q6IYF8
RefSeq (mRNA)	NM_080818 NM_001346194 NM_001346195 NM_001346196 NM_001346197	NM_001001490
RefSeq (protein)	NP_001333123 NP_001333124 NP_001333125 NP_001333126 NP_543008	NP_001001490.1 NP_001001490
Location (UCSC)	Chr 13: 96.99 – 96.99 Mb	Chr 14: 120.02 – 120.04 Mb
PubMed search

27199

239283

ENSG00000165621

ENSMUSG00000044819

Q96P68

Q6IYF8

NM_080818
NM_001346194
NM_001346195
NM_001346196
NM_001346197

NM_001001490

NP_001333123
NP_001333124
NP_001333125
NP_001333126
NP_543008

NP_001001490.1
NP_001001490

2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLT_E) and GPR99, is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene. The Gene has recently been nominated as a receptor not only for 2-oxogluterate (see alpha-Ketoglutaric acid) but also for the three cysteinyl leukotrienes (CysLTs), particularly leukotriene E4 (LTE4) and to far lesser extents LTC4 and LTE4. Recent studies implicate GPR99 as a cellular receptor which is activated by LTE4 thereby causing these cells to contribute to mediating various allergic and hypersensitivity responses.

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Wikipedia