GPBAR1

GPBAR1
Identifiers
Aliases	GPBAR1, BG37, GPCR19, GPR131, M-BAR, TGR5, G protein-coupled bile acid receptor, G protein-coupled bile acid receptor 1
External IDs	MGI: 2653863 HomoloGene: 18125 GeneCards: GPBAR1
Targeted by Drug
betulinic acid, chenodiol, cholic acid, deoxycholic acid, lithocholic acid, oleanolic acid
Gene ontology Molecular function • bile acid receptor activity • G-protein coupled receptor activity • G-protein coupled bile acid receptor activity • signal transducer activity Cellular component • cytoplasm • integral component of membrane • plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • signal transduction • cell surface bile acid receptor signaling pathway • regulation of bicellular tight junction assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	151306	227289
Ensembl	ENSG00000179921	ENSMUSG00000064272
UniProt	Q8TDU6	Q80SS6
RefSeq (mRNA)	NM_001077191 NM_001077194 NM_170699 NM_001321950	NM_174985
RefSeq (protein)	NP_001070659 NP_001070662 NP_001308879 NP_733800	NP_778150.1 NP_778150
Location (UCSC)	Chr 2: 218.26 – 218.26 Mb	Chr 1: 74.28 – 74.28 Mb
PubMed search

151306

227289

ENSG00000179921

ENSMUSG00000064272

Q8TDU6

Q80SS6

NM_001077191
NM_001077194
NM_170699
NM_001321950

NM_174985

NP_001070659
NP_001070662
NP_001308879
NP_733800

NP_778150.1
NP_778150

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene.

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This protein functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids.

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Wikipedia