GNMT

GNMT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R74, 2AZT
Identifiers
Aliases	GNMT, HEL-S-182mP, glycine N-methyltransferase
External IDs	MGI: 1202304 HomoloGene: 7741 GeneCards: GNMT
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 42,960,758 bp End 42,963,880 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 22.9 cM|17 C Start 46,725,664 bp End 46,729,168 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • folic acid binding • protein binding • glycine binding • glycine N-methyltransferase activity Cellular component • cytoplasm • cytosol Biological process • glycogen metabolic process • regulation of gluconeogenesis • methionine metabolic process • methylation • S-adenosylmethionine metabolic process • cellular protein modification process • one-carbon metabolic process • protein homotetramerization • cellular nitrogen compound metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27232	14711
Ensembl	ENSG00000124713	ENSMUSG00000002769
UniProt	Q14749	Q9QXF8
RefSeq (mRNA)	NM_018960 NM_001318865	NM_010321
RefSeq (protein)	NP_001305794 NP_061833	NP_034451
Location (UCSC)	Chr 6: 42.96 – 42.96 Mb	Chr 6: 46.73 – 46.73 Mb
PubMed search

1R74, 2AZT

27232

14711

ENSG00000124713

ENSMUSG00000002769

Q14749

Q9QXF8

NM_018960
NM_001318865

NM_010321

NP_001305794
NP_061833

NP_034451

Glycine N-methyltransferase is an enzyme that in humans is encoded by the GNMT gene.

The enzyme was first described by Blumenstein and Williams (1960) in guinea pig liver. However, this enzyme was not purified until 1972 in the rabbit liver by Kerr. In 1984, Cook and Wagner demonstrated that a liver cytosolic folate binding protein is identical to GNMT. The human GMNT gene was cloned in 2000 by Chen and coworkers.

GNMT is an abundant enzyme in liver cytosol and consists of 0.9% to 3% of the soluble protein present in liver. In addition to liver, GNMT activity has been found in a number of other tissues including pancreas and kidney. GNMT is most abundant in the peri-portal region of the liver and exocrine tissue of the pancreas. The GNMT proteins located in tissues that are actively in secretion, such as the proximal kidney tubules, the submaxillary glands and the intestinal mucosa. GNMT is also expressed in various neurons presented in the cerebral cortex, hippocampus, substantia nigra and cerebellum. The presence of GNMT in these cells suggests that this enzyme may play a role in secretion.

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