GNB5

GNB5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PBI
Identifiers
Aliases	GNB5, guanine nucleotide binding protein (G protein), beta 5, GB5, G protein subunit beta 5, LADCI, IDDCA
External IDs	MGI: 101848 HomoloGene: 40714 GeneCards: GNB5
Gene ontology Molecular function • G-protein gamma-subunit binding • chaperone binding • protein binding • signal transducer activity • GTPase activity • GTPase activator activity Cellular component • membrane • cytosol • GTPase activator complex • photoreceptor outer segment • photoreceptor inner segment • nucleus • plasma membrane • myelin sheath Biological process • positive regulation of GTPase activity • negative regulation of voltage-gated calcium channel activity • signal transduction • protein folding • dopamine receptor signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10681	14697
Ensembl	ENSG00000069966	ENSMUSG00000032192
UniProt	O14775	P62881
RefSeq (mRNA)	NM_006578 NM_016194	NM_010313 NM_138719
RefSeq (protein)	NP_006569 NP_057278 NP_006569.1	NP_034443 NP_619733
Location (UCSC)	Chr 15: 52.12 – 52.19 Mb	Chr 9: 75.31 – 75.35 Mb
PubMed search

2PBI

10681

14697

ENSG00000069966

ENSMUSG00000032192

O14775

P62881

NM_006578
NM_016194

NM_010313
NM_138719

NP_006569
NP_057278
NP_006569.1

NP_034443
NP_619733

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.

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