GLMN

GLMN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F52
Identifiers
Aliases	GLMN, FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM, glomulin, FKBP associated protein
External IDs	MGI: 2141180 HomoloGene: 14239 GeneCards: GLMN
Gene ontology Molecular function • ubiquitin-protein transferase inhibitor activity • protein binding • ubiquitin protein ligase binding • hepatocyte growth factor receptor binding Cellular component • Cul4A-RING E3 ubiquitin ligase complex • Cul2-RING ubiquitin ligase complex • cullin-RING ubiquitin ligase complex • Cul3-RING ubiquitin ligase complex • intracellular • cytoplasm Biological process • vasculogenesis • muscle cell differentiation • positive regulation of cytokine secretion • negative regulation of T cell proliferation • neural tube closure • positive regulation of phosphorylation • circulatory system development • regulation of gene expression, epigenetic • positive regulation of interleukin-2 biosynthetic process • regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of protein ubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11146	170823
Ensembl	ENSG00000174842	ENSMUSG00000029276
UniProt	Q92990	Q8BZM1
RefSeq (mRNA)	NM_007070 NM_053274 NM_001319683	NM_001161738 NM_001161739 NM_133248
RefSeq (protein)	NP_001306612 NP_444504	NP_001155210.1 NP_001155211.1 NP_573511.2 NP_001155210 NP_001155211 NP_573511
Location (UCSC)	Chr 1: 92.25 – 92.3 Mb	Chr 5: 107.55 – 107.6 Mb
PubMed search

4F52

11146

170823

ENSG00000174842

ENSMUSG00000029276

Q92990

Q8BZM1

NM_007070
NM_053274
NM_001319683

NM_001161738
NM_001161739
NM_133248

NP_001306612
NP_444504

NP_573511

Glomulin is a protein that in humans is encoded by the GLMN gene.

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

...
Wikipedia