GLI1

GLI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GLI, 4BLB, 4KMD,%%s2GLI, 4BLB, 4KMD
Identifiers
Aliases	GLI1, GLI, GLI family zinc finger 1
External IDs	OMIM: 165220 MGI: 95727 HomoloGene: 3859 GeneCards: GLI1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • microtubule binding • chromatin binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • nucleic acid binding • transcription regulatory region DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • cytoplasm • cytosol • cilium • nucleoplasm • ciliary base • ciliary tip • axoneme • nucleus Biological process • epidermal cell differentiation • proximal/distal pattern formation • cell differentiation • pituitary gland development • regulation of transcription, DNA-templated • positive regulation of smoothened signaling pathway • lung development • positive regulation of cell migration • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • notochord regression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of DNA replication • ventral midline development • multicellular organism development • regulation of smoothened signaling pathway • liver regeneration • response to wounding • regulation of osteoblast differentiation • osteoblast differentiation • spermatogenesis • positive regulation of cell proliferation • cerebellar cortex morphogenesis • regulation of hepatocyte proliferation • canonical Wnt signaling pathway • smoothened signaling pathway • dorsal/ventral pattern formation • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • digestive tract morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2735	14632
Ensembl	ENSG00000111087	ENSMUSG00000025407
UniProt	P08151	P47806
RefSeq (mRNA)	NM_001160045 NM_001167609 NM_005269	NM_010296
RefSeq (protein)	NP_001153517 NP_001161081 NP_005260 NP_001153517 NP_001161081 NP_005260	NP_034426.2 NP_034426
Location (UCSC)	Chr 12: 57.46 – 57.47 Mb	Chr 10: 127.33 – 127.34 Mb
PubMed search

2GLI, 4BLB, 4KMD,%%s2GLI, 4BLB, 4KMD

2735

14632

ENSG00000111087

ENSMUSG00000025407

P08151

P47806

NM_001160045
NM_001167609
NM_005269

NM_010296

NP_005260

NP_034426.2
NP_034426

Zinc finger protein GLI1 also known as glioma-associated oncogene is a protein that in humans is encoded by the GLI1 gene. It was originally isolated from human glioblastoma cells.

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Wikipedia