GH receptor antagonist

GHR

Protein GHR PDB 1a22.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR

Identifiers

GHR, GHBP, GHIP, growth hormone receptor

External IDs

OMIM: 600946 MGI: 95708 HomoloGene: 134 GeneCards: GHR

Gene ontology
Molecular function	• protein homodimerization activity • growth factor binding • peptide hormone binding • protein binding • cytokine receptor activity • proline-rich region binding • protein kinase binding
Cellular component	• integral component of membrane • membrane • receptor complex • integral component of plasma membrane • extracellular region • cell surface • growth hormone receptor complex • P-body • extracellular space • cytosol • plasma membrane
Biological process	• activation of JAK2 kinase activity • insulin-like growth factor receptor signaling pathway • multicellular organism metabolic process • JAK-STAT cascade • JAK-STAT cascade involved in growth hormone signaling pathway • response to estradiol • endocytosis • allantoin metabolic process • regulation of multicellular organism growth • cytokine-mediated signaling pathway • citrate metabolic process • receptor internalization • positive regulation of tyrosine phosphorylation of Stat5 protein • response to cycloheximide • positive regulation of tyrosine phosphorylation of Stat3 protein • 2-oxoglutarate metabolic process • creatinine metabolic process • oxaloacetate metabolic process • fatty acid metabolic process • succinate metabolic process • cellular response to hormone stimulus • growth hormone receptor signaling pathway • activation of MAPK activity • taurine metabolic process • valine metabolic process • positive regulation of multicellular organism growth • positive regulation of peptidyl-tyrosine phosphorylation • creatine metabolic process • isoleucine metabolic process
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE GHR 205498 at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


2690


14600


ENSG00000112964


ENSMUSG00000055737


P10912


P16882

RefSeq (mRNA)

NM_000163 NM_001242399 NM_001242400 NM_001242401 NM_001242402
NM_001242403 NM_001242404 NM_001242405 NM_001242406 NM_001242460 NM_001242461 NM_001242462


NM_001048147 NM_001048178 NM_010284 NM_001286370

RefSeq (protein)

NP_000154 NP_001229328 NP_001229329 NP_001229330 NP_001229331
NP_001229332 NP_001229333 NP_001229334 NP_001229335 NP_001229389 NP_001229391

NP_001041643.1 NP_001273299.1 NP_034414.2 NP_001041643 NP_001273299
NP_034414

Location (UCSC)

Chr 5: 42.42 – 42.72 Mb

Chr 15: 3.32 – 3.58 Mb

PubMed search

1A22, 1AXI, 1HWG, 1HWH, 1KF9, 2AEW, 3HHR

ENSG00000112964

ENSMUSG00000055737

NM_001242403
NM_001242404
NM_001242405
NM_001242406
NM_001242460
NM_001242461
NM_001242462

NM_001048147
NM_001048178
NM_010284
NM_001286370

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Wikipedia

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