GDF7

GDF7
Identifiers
Aliases	GDF7, BMP12, growth differentiation factor 7
External IDs	OMIM: 604651 MGI: 95690 HomoloGene: 32177 GeneCards: GDF7
Gene ontology Molecular function • cytokine activity • protein homodimerization activity • protein binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • extracellular space Biological process • regulation of apoptotic process • pathway-restricted SMAD protein phosphorylation • cell fate commitment • epithelial cell differentiation • regulation of MAPK cascade • SMAD protein signal transduction • spinal cord association neuron differentiation • cell development • positive regulation of tendon cell differentiation • positive regulation of pathway-restricted SMAD protein phosphorylation • roof plate formation • BMP signaling pathway • axon guidance • reproductive structure development • positive regulation of transcription, DNA-templated • forebrain morphogenesis • gland morphogenesis • positive regulation of gene expression • positive regulation of neuron differentiation • neural tube development • branching morphogenesis of an epithelial tube • midbrain development • activin receptor signaling pathway • morphogenesis of an epithelial fold Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151449	238057
Ensembl	ENSG00000143869	ENSMUSG00000037660
UniProt	Q7Z4P5	P43029
RefSeq (mRNA)	NM_182828	NM_013527 NM_001312876
RefSeq (protein)	NP_878248	NP_001299805.1 NP_038555.1 NP_001299805 NP_038555
Location (UCSC)	Chr 2: 20.67 – 20.68 Mb	Chr 12: 8.3 – 8.3 Mb
PubMed search

151449

238057

ENSG00000143869

ENSMUSG00000037660

Q7Z4P5

P43029

NM_182828

NM_013527
NM_001312876

NP_878248

NP_001299805.1
NP_038555.1
NP_001299805
NP_038555

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.

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Wikipedia