GDF3

Identifiers

GDF3, KFS3, MCOP7, MCOPCB6, growth differentiation factor 3

External IDs

OMIM: 606522 MGI: 95686 HomoloGene: 7336 GeneCards: GDF3

Gene ontology
Molecular function	• cytokine activity • transforming growth factor beta receptor binding • growth factor activity • protein kinase binding
Cellular component	• extracellular region • extracellular space • cytoplasm
Biological process	• eye development • response to dietary excess • regulation of apoptotic process • skeletal system development • regulation of cell fate commitment • negative regulation of myoblast differentiation • endoderm development • regulation of MAPK cascade • SMAD protein signal transduction • cell development • somite rostral/caudal axis specification • positive regulation of pathway-restricted SMAD protein phosphorylation • notochord development • formation of anatomical boundary • in utero embryonic development • negative regulation of BMP signaling pathway • negative regulation of epidermal cell differentiation • mesoderm development • primitive streak formation • signal transduction • multicellular organism development • positive regulation of fat cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9573


14562

Ensembl


ENSG00000184344


ENSMUSG00000030117

UniProt


Q9NR23


Q07104

RefSeq (mRNA)


NM_020634


NM_008108

RefSeq (protein)


NP_065685


NP_032134.2 NP_032134

Location (UCSC)

Chr 12: 7.69 – 7.7 Mb

Chr 6: 122.61 – 122.61 Mb

PubMed search

NP_032134.2
NP_032134

Growth differentiation factor-3 (GDF3), also known as Vg-related gene 2 (Vgr-2) is protein that in humans is encoded by the GDF3 gene. GDF3 belongs to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members including Vg1 (found in frogs) and GDF1.

Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.

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Wikipedia