GDF2

GDF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKZ, 4FAO, 4MPL, 4YCG, 4YCI
Identifiers
Aliases	GDF2, BMP-9, BMP9, HHT5, growth differentiation factor 2
External IDs	OMIM: 605120 MGI: 1321394 HomoloGene: 32299 GeneCards: GDF2
Gene ontology Molecular function • cytokine activity • protein binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • extracellular exosome • cell • extracellular space Biological process • regulation of apoptotic process • pathway-restricted SMAD protein phosphorylation • positive regulation of endothelial cell differentiation • regulation of MAPK cascade • positive regulation of endothelial cell proliferation • blood vessel morphogenesis • negative regulation of blood vessel endothelial cell migration • cell development • SMAD protein signal transduction • ossification • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to BMP stimulus • negative regulation of DNA replication • BMP signaling pathway • positive regulation of angiogenesis • negative regulation of endothelial cell migration • negative regulation of endothelial cell proliferation • vasculogenesis • positive regulation of transcription, DNA-templated • cartilage development • positive regulation of gene expression • positive regulation of osteoblast differentiation • positive regulation of cartilage development • negative regulation of cell growth • angiogenesis • osteoblast differentiation • positive regulation of interleukin-8 production • positive regulation of BMP signaling pathway • branching involved in blood vessel morphogenesis • negative regulation of angiogenesis • negative regulation of DNA biosynthetic process • positive regulation of transcription from RNA polymerase II promoter • cellular iron ion homeostasis • activin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2658	12165
Ensembl	ENSG00000263761	ENSMUSG00000072625
UniProt	Q9UK05	Q9WV56
RefSeq (mRNA)	NM_016204	NM_019506
RefSeq (protein)	NP_057288	NP_062379.3 NP_062379
Location (UCSC)	Chr 10: 47.32 – 47.33 Mb	Chr 14: 33.94 – 33.95 Mb
PubMed search

1ZKZ, 4FAO, 4MPL, 4YCG, 4YCI

2658

12165

ENSG00000263761

ENSMUSG00000072625

Q9UK05

Q9WV56

NM_016204

NM_019506

NP_057288

NP_062379.3
NP_062379

Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily.

GDF2 contains an N-terminal TGF-beta-like pro-peptide (prodomain) (residues 56–257) and a C-terminal transforming growth factor beta superfamily domain (325–428). GDF2 (BMP9) is secreted as a pro-complex consisting of the BMP9 growth factor dimer non-covalently bound to two BMP9 prodomain molecules in an open-armed conformation.

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