GDF15

GDF15
Identifiers
Aliases	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, growth differentiation factor 15
External IDs	OMIM: 605312 MGI: 1346047 HomoloGene: 3576 GeneCards: GDF15
Gene ontology Molecular function • transforming growth factor beta receptor binding • growth factor activity • protein binding • cytokine activity Cellular component • extracellular region • extracellular exosome • nucleus • cytoplasm • extracellular space Biological process • regulation of apoptotic process • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of myoblast fusion • regulation of MAPK cascade • transforming growth factor beta receptor signaling pathway • cell development • signal transduction • BMP signaling pathway • SMAD protein signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9518	23886
Ensembl	ENSG00000130513	ENSMUSG00000038508
UniProt	Q99988	Q9Z0J7
RefSeq (mRNA)	NM_004864	NM_011819 NM_001330687
RefSeq (protein)	NP_004855	NP_035949.2 NP_001317616 NP_035949
Location (UCSC)	Chr 19: 18.37 – 18.39 Mb	Chr 8: 70.63 – 70.63 Mb
PubMed search

9518

23886

ENSG00000130513

ENSMUSG00000038508

Q99988

Q9Z0J7

NM_004864

NM_011819
NM_001330687

NP_004855

NP_035949.2
NP_001317616
NP_035949

Growth/differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.

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