GBA3

GBA3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2E9L, 2E9M, 2JFE, 2ZOX, 3VKK
Identifiers
Aliases	GBA3, CBG, CBGL1, GLUC, KLRP, glucosylceramidase beta 3 (gene/pseudogene)
External IDs	GeneCards: GBA3
Gene ontology Molecular function • beta-galactosidase activity • glycosylceramidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • beta-glucosidase activity • hydrolase activity • hydrolase activity, acting on glycosyl bonds • scopolin beta-glucosidase activity • glucosylceramidase activity Cellular component • cytoplasm • cytosol Biological process • glycosylceramide catabolic process • metabolic process • glycosphingolipid metabolic process • glycoside catabolic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57733	n/a
Ensembl	ENSG00000249948	n/a
UniProt	Q9H227	n/a
RefSeq (mRNA)	NM_001128432 NM_001277225 NM_020973	n/a
RefSeq (protein)	NP_001121904.1 NP_001264154.1 NP_066024.1 NP_001121904 NP_001264154 NP_066024	n/a
Location (UCSC)	Chr 4: 22.69 – 22.82 Mb	n/a
PubMed search		n/a

2E9L, 2E9M, 2JFE, 2ZOX, 3VKK

57733

n/a

ENSG00000249948

n/a

Q9H227

n/a

NM_001128432
NM_001277225
NM_020973

n/a

NP_066024

n/a

Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase (EC 3.2.1.21) enzyme that in humans is encoded by the GBA3 gene.

Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a non-lysosomal catabolic pathway of glucosylceramide metabolism.

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