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GAD2

GAD2
Protein GAD2 PDB 2okk.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GAD2, GAD65, glutamate decarboxylase 2
External IDs MGI: 95634 HomoloGene: 20223 GeneCards: GAD2
RNA expression pattern
PBB GE GAD2 206780 at fs.png

PBB GE GAD2 211264 at fs.png

PBB GE GAD2 216651 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001134366
NM_000818

NM_008078

RefSeq (protein)

NP_000809
NP_001127838

NP_032104.2
NP_032104

Location (UCSC) Chr 10: 26.22 – 26.3 Mb Chr 2: 22.62 – 22.69 Mb
PubMed search

1ES0, 2OKK

NM_001134366
NM_000818

NM_008078

NP_000809
NP_001127838

NP_032104.2
NP_032104

Glutamate decarboxylase 2 is an enzyme that in humans is encoded by the GAD2 gene.

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff person syndrome.


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Wikipedia

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