GABRD
| GABRD | ||||||
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| Identifiers | ||||||
| Aliases | GABRD, EIG10, EJM7, GEFSP5, gamma-aminobutyric acid type A receptor delta subunit | |||||
| External IDs | MGI: 95622 HomoloGene: 55489 GeneCards: GABRD | |||||
| Targeted by Drug | ||||||
| gaboxadol, picrotoxin | ||||||
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| Species | Human | Mouse | ||||
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| Location (UCSC) | Chr 1: 2.02 – 2.03 Mb | Chr 4: 155.38 – 155.4 Mb | ||||
| PubMed search | ||||||
Gamma-aminobutyric acid receptor subunit delta is a protein that in humans is encoded by the GABRD gene.
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABAA receptors, which are ligand-gated chloride channels. The GABAA receptor is generally pentameric. Its five subunits are alpha, beta, gamma, delta, and rho. The GABRD gene encodes the delta subunit.
In a technical comparison between quantitative reverse transcriptase PCR and digital PCR, the expression of the rat gabrd gene was examined across three cell types in the somatosensory cortex: neurogliaform cells, fast spiking basket cells and pyramidal cells. Gene expression was detected in all three cell types, but showed marked enrichment in neurogliaform cells versus the other cell types examined.
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