GABRA5

GABRA5
Identifiers
Aliases	GABRA5, gamma-aminobutyric acid type A receptor alpha5 subunit
External IDs	MGI: 95617 HomoloGene: 20219 GeneCards: GABRA5
Gene ontology Molecular function • GABA-A receptor activity • GABA receptor binding • transporter activity • ion channel activity • chloride channel activity • extracellular ligand-gated ion channel activity • receptor activity Cellular component • integral component of membrane • cell body • GABA-A receptor complex • postsynaptic membrane • membrane • receptor complex • plasma membrane • synapse • integral component of plasma membrane • chloride channel complex • neuronal cell body membrane • dendrite • cell junction Biological process • gamma-aminobutyric acid signaling pathway • negative regulation of neuron apoptotic process • cochlea development • associative learning • regulation of neuron apoptotic process • neuron development • chloride transmembrane transport • sensory perception of sound • ion transport • behavioral fear response • ion transmembrane transport • brain development • inner ear receptor cell development • transport • chloride transport • innervation • signal transduction • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2558	110886
Ensembl	ENSG00000186297	ENSMUSG00000055078
UniProt	P31644	Q8BHJ7
RefSeq (mRNA)	NM_000810 NM_001165037	NM_176942
RefSeq (protein)	NP_000801 NP_001158509	NP_795916.1 NP_795916
Location (UCSC)	Chr 15: 26.87 – 26.95 Mb	Chr 7: 57.41 – 57.51 Mb
PubMed search

2558

110886

ENSG00000186297

ENSMUSG00000055078

P31644

Q8BHJ7

NM_000810
NM_001165037

NM_176942

NP_000801
NP_001158509

NP_795916.1
NP_795916

Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA_A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA_A receptor. At least 16 distinct subunits of GABA_A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.

...
Wikipedia